Molecular-Hydrogen, a Natural Resource for Health, in the Context of Modern Life
Abstract
Objectives. The aims of this paper is to highlight the importance of molecular hydrogen (MH) as a natural resource for health, in the context of modern life.
Prior Work. Hydrogen is an essential chemical element present in our universe. Scientific studies have suggested that MH may have beneficial effects on different conditions and diseases, such as inflammatory, neurodegenerative, metabolic disorders, tissue damage due to ischemia-reperfusion.
Approach. Oxygen, a molecule essential to life, is likely to cause damage in the body via the formation of free radicals, also called activated oxygen species. Hydrogen exists in several forms but we find it mainly in the molecular form of hydrogen also called diatomic form, or dihydrogen.
Results. Due to its small size MH can easily penetrate cells and act directly on free radicals. Unlike many other antioxidants, it does not neutralize reactive species necessary for essential cellular functions, making it an antioxidant without unwanted side effects. MH is easily accessible, it can be inhaled, dissolved in water or administered intravenously, which allows various options for use, especially as an antioxidant.
Value. Overall, this paper presents some important antioxidative mechanisms of MH, forms and methods of use and its benefits as an antioxidant.
References
Aoki, K.; Nakao, A.; Adachi, T.; Matsui, Y. & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on
muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, Vol. 2.
Buxton, G. V.; Greenstock, C. L.; Helman, W. P. & Ross, A. B. (1988). Critical review of rate constants for reactions of
hydrated electrons, hydrogen atoms and hydroxyl radicals (OH/-O) in aqueous solution. Journal of Physical and Chemical
Reference Data, Vol. 17(2), pp. 513-886.
Chen, M.; Zhang, J.; Chen, Y.; Qiu, Y.; Luo, Z. & Zhao, S. et al. (2018). Hydrogen protects lung from hypoxia/re-oxygenation
injury by reducing hydroxyl radical production and inhibiting inflammatory responses. Scientific Reports, Vol. 8.
Ding, S.; Xu, S.; Ma, Y.; Liu, G.; Jang, H. & Fang, J. (2019). Modulatory Mechanisms of the NLRP3 Inflammasomes in
Diabetes. Biomolecules, Vol. 9(12).
Dobashi, S.; Takeuchi, K. & Koyama, K. (2020). Hydrogen-rich water suppresses the reduction in blood total antioxidant
capacity induced by 3 consecutive days of severe exercise in physically active males. Medical Gas Research, Vol. 10(1), pp.
-26.
Fu, Z. & Zhang, J. (2022). Molecular hydrogen is a promising therapeutic agent for pulmonary disease. Journal of Zhejiang
University-Science B, Vol. 23(2), pp. 102-122.
Halliwell, B. & Gutteridge, J. M. C. (2015). Free Radicals in Biologiy & Medicine. 5th Edition. Auflage. New York: Oxford
University Press.
Hori, A.; Sobue, S.; Kurokawa, R.; Hirano, S. I.; Ichihara, M. & Hotta, N. (2020). Two-week continuous supplementation of
hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized,
single-blinded, placebo-controlled study. Medical Gas Research, Vol. 10(4), pp. 163-169.
Ichihara, M.; Sobue, S.; Ito, M.; Ito, M.; Hirayama, M. & Ohno, K. (2015). Beneficial biological effects and the underlying
mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Medical Gas Research, Vol. 5(1).
Jurcau, R.N.; Jurcau, I.M. & Colceriu, N.A. (2023). Molecular hydrogen, a therapeutic gas with antioxidant effects, general
aspects and mechanisms. Health, Sports & Rehabilitation Medicine, Vol. 24(1), pp. 32-37.
Kim, Y. G.; Kim, S. M.; Kim, K. P.; Lee, S. H. & Moon, J. Y. (2019). The Role of Inflammasome-Dependent and
Inflammasome-Independent NLRP3 in the Kidney. Cells, Vol. 8(11).
Kimura, H. (2010). Hydrogen sulfide: from brain to gut. Antioxid Redox Signal, Vol. 12(9), pp. 1111-1123.
Motterlini, R. & Otterbein, L. E. (2010). The therapeutic potential of carbon monoxide. Nature Reviews Drug Discovery, Vol.
(9), pp. 728-743.
Mridha, A. R.; Wree, A.; Robertson, A. A. B.; Yeh, M. M.; Johnson, C. D.; Van Rooyen, D. M.; Haczeyni, F.; Teoh, N. C.;
Savard, C.; Ioannou, G. N.; Masters, S. L.; Schroder, K.; Cooper, M. A.; Feldstein, A. E. & Farrell, G. C. (2017). NLRP3
inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, Vol.
(5), pp. 1037-1046.
Ohta, S. (2014). Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of
hydrogen medicine. Pharmacology & Therapeutics, Vol. 144(1), pp. 1-11.
Ostojic, S. M. (2015). Molecular hydrogen in sports medicine: new therapeutic perspectives. International Journal of Sports
Medicine, Vol. 36(4), pp. 273-279.
Ostojic, S.M. (2018). Inadequate Production of H 2 by Gut Microbiota and Parkinson Disease. Trends in Endocrinology &
Metabolism, Vol. 29(5), pp. 286-288.
Qin, Y.; Qiu, J.; Wang, P.; Liu, J.; Zhao, Y.; Jiang, F. & Lou, H. (2021). Impaired autophagy in microglia aggravates
dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s
disease. Brain, Behavior and Immunity, Vol. 91, pp. 324-338.
Shibayama, Y.; Dobashi, S.; Arisawa, T.; Fukuoka, T. & Koyama, K. (2020). Impact of hydrogen-rich gas mixture inhalation
through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage and exercise
performances in men. Medical Gas Research, Vol. 10(4), pp. 155-162.
Socha, M. W.; Malinowski, B.; Puk, O.; Dubiel, M. & Wicinski, M. (2020). The NLRP3 Inflammasome Role in the
Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia. Cells, Vol. 9.
Tian, Y.; Zhang, Y.; Wang, Y.; Chen, Y.; Fan, W.; Zhou, J.; Qiao, J. & Wei, Y. (2021). Hydrogen, a Novel Therapeutic
Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Frontiers in Physiology, Vol. 12.
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